Endothelins are proteins that constrict blood vessels and raise blood pressure. They are normally kept in balance by other mechanisms, but when they are over-expressed, they contribute to high blood pressure (hypertension) and heart disease.
The ubiquitous distribution of endothelin peptides and receptors implicates its involvement in a wide variety of physiological and pathological processes in the body. Among numerous diseases potentially occurring from endothelin dysregulation are: several types of cancer; cerebral vasospasm following subarachnoid hemorrhage; arterial hypertension and other cardiovascular disorders; pain mediation
Prof. S.K.Brahmachari, former Director of Institute of Genomics and Integrative Biology, IGIB and current Director General of CSIR and DSIR.
He is one of the premiere geneticists of India and pioneered the Bioinformatics revolution in IGIB. He is one of the select few to initiate large scale genetic studies of human diseases with a well built-in model framework for integration of clinical institutions and science research organizations in India. In his tenure as the director of IGIB he has initiated various projects aimed at translational research including mapping Indian genetic variations for disease gene exploration.Part 1
DU145 (DU-145) and PC3 human prostate cancer cell lines are the "classical" cell lines of prostatic cancer. DU145 cells have moderate metastatic potential compared to PC3 cells which have high metastatic potential.
The DU145 cell line was derived from brain metastasis. DU145 are not hormone sensitive and don’t express PSA (Prostate Specific Antigen)